HUU - Hyperuricosuria

In affected dogs, uric acid does not dissolve easily in urine and accumulates. The excessive amount of uric acid
forms crystals which lead to urinary calculi (stones), which may require surgery.

Clinical signs?
The changes in the urine are generally present from birth. However it usually takes some time for crystals to
form and combine into stones that cause problems, most often between 3 and 6 years of age. The signs you will
see in your dog depend on where in the urinary tract the stones end up. They collect most commonly in the bladder,
in which case you may see blood in the urine, difficulty and pain in urinating, and small frequent amounts of urine.Urinary tract obstruction is a serious condition that occurs when a stone completely blocks the urethra and blocks the outflow of urine (more common in male dogs that have a smaller urethra). Signs include straining to urinate, vomiting and loss of appetite, weakness and lethargy (lack of energy), due to toxins building up in the body.

How it is inherited?
The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies
of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog
that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the
disease, but will be a carrier and may pass the gene on to any offspring.